![]() ![]() ![]() Ureases, a virulence factor in Proteus mirabilis, cause an increase in urine pH - leading to blockage. Catheter blockage can be dangerous and increases the risk of severe infections, such as sepsis. Catheter-associated urinary tract infections resulting from urease-positive microorganisms are more likely to cause a urinary catheter blockage owing to the urease activity of the microbes.
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